Radiation-Induced Bystander Effect Research: Literature Review

The aim of the present study is to review literature on radiation-induced bystander effect research. The radiation-induced bystander effect concerns a plethora of biological phenomena occurring in non-irradiated cells as a result of signal transmission from irradiated cells. This paper discusses many radiation-induced bystander effect in vitro experiments, e.g., for numerous types of cell lines or tumor cells. The influence of nanomaterials on the radiation-induced bystander effect is analyzed. Moreover, the relationship between the radiation-induced bystander effect and the radiation-induced senescence, inflammatory pathways and endothelial cells is discussed. The authors have tried to explore as many mechanisms accompanying the radiation-induced bystander effect as possible. The in-depth mechanism research on cell proliferation influenced by the bystander effect of radiation will be useful to understand the biological effects of radiation.