p21Waf1/Cip1 as a molecular sensor for BoHV-4 replication

被引：3
|
作者：
Capocefalo, A. [1 ]
Franceschi, V. [1 ]
Whitelaw, C. B. A. [2 ,3 ]
Vasey, D. B. [2 ,3 ]
Lillico, S. G. [2 ,3 ]
Cavirani, S. [1 ]
Donofrio, G. [1 ]
机构：
[1] Fac Med Vet, Dipartimento Salute Anim, Sez Malattie Infett Anim, I-43100 Parma, Italy
[2] Univ Edinburgh, Div Dev Biol, Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland
[3] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin EH25 9PS, Midlothian, Scotland
来源：
JOURNAL OF VIROLOGICAL METHODS | 2009年 / 161卷 / 02期
基金：
英国生物技术与生命科学研究理事会;
关键词：
BoHV-4; p21(Waf1/Cip1); Cellular damage; CYCLIN-DEPENDENT KINASES; BOVINE HERPESVIRUS-4; DNA-DAMAGE; P21; IDENTIFICATION; INHIBITION; VIRUS; P53;
D O I：
10.1016/j.jviromet.2009.06.012
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
BoHV-4 replication cycle is dependent on the S-phase of the cell-cycle at the stage of viral DNA synthesis. Because p21 is a rate-limiting regulator of the G1/S-phase transition and up-regulated by DNA-damaging agents, in this study p21 expression in BoHV-4 infected cells was investigated. The p21 promoter was found to be highly activated in a dose- and time-dependent manner following BoHV-4 infection only in cells which are permissive for BoHV-4 replication. Thus p21 expression reports on BoHV-4 replication and could represent a host cell defensive response to infection-associated cellular damage. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：308 / 311
页数：4
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