Peripheral neuropathy in primary Sjogren syndrome - A population-based study

被引:92
|
作者
Goransson, Lasse G.
Herigstad, Anita
Tjensvoll, Anne B.
Harboe, Erna
Mellgren, Svein I.
Omdal, Roald
机构
[1] Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, N-4068 Stavanger, Norway
[2] Stavanger Univ Hosp, Dept Clin Neurophysiol, N-4068 Stavanger, Norway
[3] Stavanger Univ Hosp, Dept Neurol, N-4068 Stavanger, Norway
[4] Univ Bergen, Inst Internal Med, N-5020 Bergen, Norway
[5] Univ Tromso, Inst Clin Med, N-9001 Tromso, Norway
[6] Univ Hosp N Norway, Dept Neurol, Tromso, Norway
关键词
D O I
10.1001/archneur.63.11.1612
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Neurological manifestations appear to be frequently involved in patients with primary Sjogren syndrome (PSS). Objective: To investigate the involvement of the peripheral nervous system, including small-diameter nerve fibers, in an unselected cohort of patients who fulfilled the new international criteria for PSS. Design: Cross-sectional study. Setting: Stavanger University Hospital. Patients: Sixty-two patients with PSS (mean +/- SD age, 57.1 +/- 14.6 years). Interventions: Clinical neurologic examinations, conventional nerve conduction studies, and skin punch biopsies. Main Outcome Measures: Signs of large-diameter and small-diameter peripheral nerve fiber neuropathy as determined by clinical examination, nerve conduction studies, and densities of intraepidermal nerve fibers in skin punch biopsy specimens. Results: Seventeen patients (27%) were diagnosed as having neuropathy after clinical examination. The results of nerve conduction studies were abnormal in 34 patients (55%): 19 patients (31%) had motor neuropathy, 8 (13%) had sensory neuropathy, and 7 (11%) had sensorimotor neuropathy. Two patients had intraepidermal nerve fiber densities less than 3.4 fibers per millimeter, fitting the morphologic criteria for small-diameter nerve fiber neuropathy. Conclusions: Peripheral neuropathy occurs in a large proportion of patients with PSS, in most cases as a subclinical demyelinating neuropathy. Small-diameter nerve fiber neuropathy is not a frequent finding in these patients.
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页码:1612 / 1615
页数:4
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