Abdominal Surgery in Patients With Idiopathic Noncirrhotic Portal Hypertension: A Multicenter Retrospective Study

被引：13

作者：

Elkrief, Laure ^{[1
,2
]}

Ferrusquia-Acosta, Jose ^{[3
,4
]}

Payance, Audrey ^{[5
]}

Moga, Lucile ^{[6
]}

Tellez, Luis ^{[7
]}

Praktiknjo, Michael ^{[8
]}

Procopet, Bogdan ^{[9
]}

Farcau, Oana ^{[9
,10
]}

De Ledinghen, Victor ^{[11
]}

Yuldashev, Rustam ^{[12
]}

Tabchouri, Nicolas ^{[13
,14
]}

Barbier, Louise ^{[13
,14
]}

Dumortier, Jerome ^{[15
]}

Menahem, Benjamin ^{[16
]}

Magaz, Marta ^{[3
,4
]}

Hernandez-Gea, Virginia ^{[3
,4
]}

Albillos, Agustin ^{[7
]}

Trebicka, Jonel ^{[8
]}

Spahr, Laurent ^{[2
]}

De Gottardi, Andrea ^{[10
]}

Plessier, Aurelie ^{[5
]}

Valla, Dominique ^{[5
]}

Rubbia-Brandt, Laura ^{[17
]}

Toso, Christian ^{[1
,18
]}

Bureau, Christophe ^{[6
]}

Garcia-Pagan, Juan-Carlos ^{[3
,4
]}

Rautou, Pierre-Emmanuel ^{[5
,19
,20
]}

机构：

[1] Hop Univ Geneve, Serv Transplantat, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland

[2] Hop Univ Geneve, Serv Hepatogastroenterol, Geneva, Switzerland

[3] Hosp Clin Barcelona, Hepat Hemodynam Lab, European Reference Network Rare Liver Disorders, Liver Unit,IDIBAPS, Barcelona, Spain

[4] CIBERehd, Barcelona, Spain

[5] Hop Beaujon, AP HP, Ctr Reference Malad Vasc Foie, Serv Hepatol,DHU Unity,Pole Malad Appareil Digest, Clichy, France

[6] CHU Toulouse, Serv Hepatogastroenterol, Toulouse, France

[7] Hosp Univ Ramon & Cajal, Dept Gastroenterol & Hepatol, Madrid, Spain

[8] Univ Klinikum, Lab Liver Fibrosis & Portal Hypertens, Bonn, Germany

[9] Univ Med & Pharm luliu Hatieganu, Reg Inst Gastroenterol & Hepatol O Fodor, Dept Gastroenterol, Med Clin 3, Cluj Napoca, Romania

[10] Intelspital, Dept Visceral Surg & Med, Bern, Switzerland

[11] Hop Haut Leveque, Serv Hepatogastroenterol, Bordeaux, France

[12] Republican Specialized Sci Pract Med Ctr Pediat, Tashkent, Uzbekistan

[13] Hop Trousseau, Serv Chirurg Digest Oncol Endocrinienne & Transpl, Tours, France

[14] Hop Trousseau, FHU SUPORT, Tours, France

[15] Univ Claude Bernard Lyon 1, Dept Digest Dis, Hosp Civils Lyon, Hop Edouard Herriot, Lyon, France

[16] Univ Hosp Caen, Dept Digest Surg, Caen, France

[17] Hop Univ Geneve, Serv Pathol Clin, Geneva, Switzerland

[18] Hop Univ Geneve, Serv Chirurg Viscerale, Geneva, Switzerland

[19] Univ Denis Diderot Paris 7, Sorbonne Paris Cite, Paris, France

[20] Paris Cardiovasc Res Ctr PARCC, INSERM, UMR 970, Paris, France

来源：

HEPATOLOGY | 2019年 / 70卷 / 03期

关键词：

INTRAHEPATIC PORTOSYSTEMIC SHUNT; NODULAR REGENERATIVE HYPERPLASIA; CIRRHOTIC-PATIENTS; RISK-FACTORS; VEIN-THROMBOSIS; CONSENSUS WORKSHOP; MORTALITY; LIVER; COMPLICATIONS; CLASSIFICATION;

D O I：

10.1002/hep.30628

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In patients with idiopathic noncirrhotic portal hypertension (INCPH), data on morbidity and mortality of abdominal surgery are scarce. We retrospectively analyzed the charts of patients with INCPH undergoing abdominal surgery within the Vascular Liver Disease Interest Group network. Forty-four patients with biopsy-proven INCPH were included. Twenty-five (57%) patients had one or more extrahepatic conditions related to INCPH, and 16 (36%) had a history of ascites. Forty-five procedures were performed, including 30 that were minor and 15 major. Nine (20%) patients had one or more Dindo-Clavien grade >= 3 complication within 1 month after surgery. Sixteen (33%) patients had one or more portal hypertension-related complication within 3 months after surgery. Extrahepatic conditions related to INCPH (P = 0.03) and history of ascites (P = 0.02) were associated with portal hypertension-related complications within 3 months after surgery. Splenectomy was associated with development of portal vein thrombosis after surgery (P = 0.01). Four (9%) patients died within 6 months after surgery. Six-month cumulative risk of death was higher in patients with serum creatinine >= 100 mu mol/L at surgery (33% versus 0%, P < 0.001). An unfavorable outcome (i.e., either liver or surgical complication or death) occurred in 22 (50%) patients and was associated with the presence of extrahepatic conditions related to INCPH, history of ascites, and serum creatinine >= 100 mu mol/L: 5% of the patients with none of these features had an unfavorable outcome versus 32% and 64% when one or two or more features were present, respectively. Portal decompression procedures prior to surgery (n = 10) were not associated with postoperative outcome. Conclusion: Patients with INCPH are at high risk of major surgical and portal hypertension-related complications when they harbor extrahepatic conditions related to INCPH, history of ascites, or increased serum creatinine.

引用

页码：911 / 924

页数：14

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