[1] Tohoku Univ, Grad Sch Pharmaceut Sci & Med, Dept Clin Pharmacol, Sendai, Miyagi 980, Japan
[2] Tohoku Univ, Grad Sch Pharmaceut Sci & Med, Dept Planning Drug Dev & Clin Evaluat, Sendai, Miyagi 980, Japan
[3] Tohoku Univ, 21st Century COE Program, CRESCENDO, Sendai, Miyagi 980, Japan
[4] Ohasama Hosp, Iwate, Japan
[5] Tohoku Univ, Sch Med, Dept Environm Hlth Sci, Sendai, Miyagi 980, Japan