4-Hydroxy-2-quinolones. 154. Pyrimidin-2-ylamides of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. Synthesis, structure, and properties

被引：5

作者：

Ukrainets, I. V. ^{[1
]}

Tkach, A. A. ^{[1
]}

Grinevich, L. A. ^{[1
]}

Turov, A. V. ^{[2
]}

Bevz, O. V. ^{[1
]}

机构：

[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine

[2] Taras Shevchenko Natl Univ, UA-01033 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2009年 / 45卷 / 05期

关键词：

2-aminopyrimidine; 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides; bromination; antitubercular activity; X-ray structural analysis; PYRIMIDINE; INHIBITORS; ISSUES; POTENT;

D O I：

10.1007/s10593-009-0297-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a series of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids pyrimidin-2-ylamides has been carried out with the aim of subsequent microbiological investigation. In acetic acid it was found that these compounds are brominated by 1 equivalent of bromine at position 5 of the pyrimidine ring. The only exception is the 1-allyl derivative which undergoes heterocyclization under these conditions to give 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a]quinoline-4-carboxylic acid pyrimidin-2-ylamide. The results of a study of the antitubercular activity of the synthesized compounds are presented.

引用

页码：567 / 579

页数：13

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