The rotary binding change mechanism of ATP synthases

被引：59
|
作者：
Cross, RL [1 ]
机构：
[1] SUNY Hlth Sci Ctr, Dept Biochem & Mol Biol, Syracuse, NY 13210 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2000年 / 1458卷 / 2-3期
关键词：
F0F1 ATP synthase; binding change mechanism; rotational catalysis; oxidative phosphorylation;
D O I：
10.1016/S0005-2728(00)00079-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The F0F1 ATP synthase functions as a rotary motor where subunit rotation driven by a current of protons flowing through F-0 drives the binding changes in F-1 that are required for net ATP synthesis. Recent work that has led to the identification of components of the rotor and stator is reviewed. In addition, a model is proposed to describe the transmission of energy from four proton transport steps to the synthesis of one ATP. Finally, some of the requirements for efficient energy coupling by a rotary binding change mechanism are considered. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：270 / 275
页数：6
相关论文
共 50 条
  • [41] Energy coupling mechanism of FO in a rotary ATP synthase:a model update
    Xuejun C.Zhang
    Min Liu
    BiophysicsReports, 2019, 5 (02) : 61 - 64
  • [42] ATP Synthases in the Year 2000: Defining the Different Levels of Mechanism and Getting a Grip on Each
    Peter L. Pedersen
    Young Hee Ko
    Sangjin Hong
    Journal of Bioenergetics and Biomembranes, 2000, 32 : 423 - 432
  • [43] STRUCTURE AND MECHANISM OF F0F1-TYPE ATP SYNTHASES AND ATPASES
    PENEFSKY, HS
    CROSS, RL
    ADVANCES IN ENZYMOLOGY AND RELATED AREAS OF MOLECULAR BIOLOGY, 1991, 64 : 173 - 214
  • [44] ATP synthases in the year 2000: Defining the different levels of mechanism and getting a grip on each
    Pedersen, PL
    Ko, YH
    Hong, SJ
    JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2000, 32 (05) : 423 - 432
  • [45] ATP SYNTHASES STRUCTURE OF THE F1-MOIETY AND ITS RELATIONSHIP TO FUNCTION AND MECHANISM
    YSERN, X
    AMZEL, LM
    PEDERSEN, PL
    JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1988, 20 (04) : 423 - 450
  • [46] MECHANISM OF ATP BINDING AT ATPASE SITE OF NITROGENASE - STUDIES WITH ATP ANALOGS
    SADKOV, AP
    GVOZDEV, RI
    BIOORGANICHESKAYA KHIMIYA, 1975, 1 (05): : 652 - 658
  • [47] CHLOROPLAST AND PLANT MITOCHONDRIAL ATP SYNTHASES
    GLASER, E
    NORLING, B
    CURRENT TOPICS IN BIOENERGETICS, 1991, 16 : 223 - 263
  • [48] The persistent homology of mitochondrial ATP synthases
    Sinha, Savar D.
    Wideman, Jeremy G.
    ISCIENCE, 2023, 26 (05)
  • [49] Cryo-EM of ATP synthases
    Guo, Hui
    Rubinstein, John L.
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2018, 52 : 71 - 79
  • [50] Binding of single nucleotides to H+-ATP synthases observed by fluorescence resonance energy transfer
    Steigmiller, S
    Zimmermann, B
    Diez, M
    Börsch, M
    Gräber, P
    BIOELECTROCHEMISTRY, 2004, 63 (1-2) : 79 - 85
12345