Synthesis of 1-Aminocarbonylmethyl-5-aryl-4-aroyl-3-hydroxy-3-pyrroline-2-ones

被引：0
|
作者：
Gein, V. L. [1 ]
Pastukhova, E. V. [1 ]
机构：
[1] Perm State Pharmaceut Acad, Perm 614990, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 01期
关键词：
1-aminocarbonylmethyl-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones; glycinamide hydrochloride; tetrahydropyrrol-2; 3-diones; three-component reactions;
D O I：
10.1134/S1070363221010035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of new 1-aminocarbonylmethyl-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones has been synthesized through a three-component reaction of aroylpyruvic acid methyl ester with a mixture of aromatic aldehyde and glycinamide hydrochloride in glacial acetic acid in the presence of anhydrous sodium bicarbonate.
引用
收藏
页码：40 / 43
页数：4
相关论文
共 50 条
  • [41] Synthesis and Antibacterial Activity of 1-(4-Aminosulfonylphenyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones
    V. L. Gein
    T. F. Odegova
    K. A. Tkachenko
    O. V. Bobrovskaya
    M. I. Vakhrin
    Pharmaceutical Chemistry Journal, 2013, 47 : 371 - 373
  • [42] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1-(4-HYDROXYPHENYL)-4-ACYL-5-ARYL-3-HYDROXY-3-PYRROLIN-2-ONES
    Gein, V. L.
    Armisheva, M. N.
    Rassudikhina, N. A.
    Vakhrin, M. I.
    Voronina, E. V.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2011, 45 (03) : 162 - 164
  • [43] Synthesis and Some Transformations of 5-Aryl-4-(4-halogenaroyl)-3-hydroxy-1-cyanomethyl-3-pyrrolin-2-ones
    Gein, V. L.
    Pastukhova, E. V.
    Korol, A. N.
    Dozmorova, N. V.
    Voronina, E. V.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2020, 90 (12) : 2225 - 2229
  • [44] Synthesis and Some Transformations of 5-Aryl-4-(4-halogenaroyl)-3-hydroxy-1-cyanomethyl-3-pyrrolin-2-ones
    V. L. Gein
    E. V. Pastukhova
    A. N. Korol
    N. V. Dozmorova
    E. V. Voronina
    Russian Journal of General Chemistry, 2020, 90 : 2225 - 2229
  • [45] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1-(4-AMINOSULFONYLPHENYL)-5-ARYL-4-ACYL-3-HYDROXY-3-PYRROLIN-2-ONES
    Gein, V. L.
    Odegova, T. F.
    Tkachenko, K. A.
    Bobrovskaya, O. V.
    Vakhrin, M. I.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2013, 47 (07) : 371 - 373
  • [46] Synthesis and Antibacterial and Immunobiological Activity of Ethyl-1-(4-Aminosulfonylphenyl)-5-Aryl-3-Hydroxy-2-Oxo-3-Pyrroline-4-Carboxylates
    V. L. Gein
    O. V. Bobrovskaya
    T. F. Odegova
    I. V. Krylova
    O. N. Gein
    E. É. Sopova
    S. V. Gein
    Pharmaceutical Chemistry Journal, 2016, 49 : 677 - 679
  • [47] SYNTHESIS AND ANTIBACTERIAL AND IMMUNOBIOLOGICAL ACTIVITY OF ETHYL-1-(4-AMINOSULFONYLPHENYL)-5ARYL-3-HYDROXY-2-OXO-3-PYRROLINE-4-CARBOXYLATES
    Gein, V. L.
    Bobrovskaya, O. V.
    Odegova, T. F.
    Krylova, I. V.
    Gein, O. N.
    Sopova, E. E.
    Gein, S. V.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2016, 49 (10) : 677 - 679
  • [48] Synthesis and Analgesic and Anti-Inflammatoryactivity of 5-aryl-4-acetyl-3-hydroxy-1-carboxymethyl-3-pyrrolin-2-ones
    Gein, V. L.
    Pastukhova, E., V
    Chashchina, S., V
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2022, 56 (03) : 321 - 324
  • [49] Synthesis and biological activity of 4-acyl-5-aryl-3-hydroxy-1-(2- hydroxyethylaminoethyl)-3-pyrrolin-2-ones
    Gein V.L.
    Kasimova N.N.
    Moiseev A.L.
    Sheptukha M.A.
    Syropyatov B.Ya.
    Ismailova N.G.
    Voronina E.V.
    Ivanenko O.I.
    Pharmaceutical Chemistry Journal, 2007, 41 (9) : 476 - 479
  • [50] Synthesis and Analgesic and Anti-Inflammatoryactivity of 5-aryl-4-acetyl-3-hydroxy-1-carboxymethyl-3-pyrrolin-2-ones
    V. L. Gein
    E. V. Pastukhova
    S. V. Chashchina
    Pharmaceutical Chemistry Journal, 2022, 56 : 321 - 324
12345