Neuroprotective Effects of Stem Cells in Ischemic Stroke

被引：37
|
作者：
Xu, Weilin [1 ]
Zheng, Jingwei [1 ]
Gao, Liansheng [1 ]
Li, Tao [1 ]
Zhang, Jianmin [1 ,2 ,3 ]
Shao, Anwen [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurosurg, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Brain Res Inst, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Collaborat Innovat Ctr Brain Sci, Hangzhou, Zhejiang, Peoples R China
来源：
STEM CELLS INTERNATIONAL | 2017年 / 2017卷
基金：
中国博士后科学基金;
关键词：
FOCAL CEREBRAL-ISCHEMIA; MARROW STROMAL CELLS; THERAPEUTIC BENEFIT; FUNCTIONAL RECOVERY; NEURONAL APOPTOSIS; DENTATE GYRUS; UP-REGULATION; ADULT RATS; TRANSPLANTATION; BRAIN;
D O I：
10.1155/2017/4653936
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Ischemic stroke, the most common subtype of stroke, has been one of the leading causes of mobility and mortality worldwide. However, it is still lacking of efficient agents. Stem cell therapy, with its vigorous advantages, has attracted researchers around the world. Numerous experimental researches in animal models of stroke have demonstrated the promising efficacy in treating ischemic stroke. The underlying mechanism involved antiapoptosis, anti-inflammation, promotion of angiogenesis and neurogenesis, formation of new neural cells and neuronal circuitry, antioxidation, and blood-brain barrier (BBB) protection. This review would focus on the types and neuroprotective actions of stem cells and its potential mechanisms for ischemic stroke.
引用
收藏
页数：7
相关论文
共 50 条
  • [31] Neural Stem Cells for Early Ischemic Stroke
    Hamblin, Milton H.
    Lee, Jean-Pyo
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (14)
  • [32] Pathophysiology Stem Cells for the Therapy of ischemic Stroke
    Doeppner, T.
    AKTUELLE NEUROLOGIE, 2015, 42 (05) : E46 - E46
  • [33] Clinical trials of stem cells for ischemic stroke
    Freitas, G.
    BRAIN PATHOLOGY, 2014, 24 : 30 - 30
  • [34] Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats
    Koh, Seong-Ho
    Kim, Kyung Suk
    Choi, Mi Ran
    Jung, Kyoung Hwa
    Park, Kyoung Sun
    Chai, Young Gyu
    Roh, Wonjae
    Hwang, Se Jin
    Ko, Hyun-Ju
    Huh, Yong-Min
    Kim, Hee-Tae
    Kim, Seung Hyun
    BRAIN RESEARCH, 2008, 1229 : 233 - 248
  • [35] Neuroprotective effects of long noncoding RNAs involved in ischemic postconditioning after ischemic stroke
    Wei Ma
    Chun-Yan Li
    Si-Jia Zhang
    Cheng-Hao Zang
    Jin-Wei Yang
    Zhen Wu
    Guo-Dong Wang
    Jie Liu
    Wei Liu
    Kuang-Pin Liu
    Yu Liang
    Xing-Kui Zhang
    Jun-Jun Li
    Jian-Hui Guo
    Li-Yan Li
    NeuralRegenerationResearch, 2022, 17 (06) : 1299 - 1309
  • [36] Neuroprotective effects of long noncoding RNAs involved in ischemic postconditioning after ischemic stroke
    Ma, Wei
    Li, Chun-Yan
    Zhang, Si-Jia
    Zang, Cheng-Hao
    Yang, Jin-Wei
    Wu, Zhen
    Wang, Guo-Dong
    Liu, Jie
    Liu, Wei
    Liu, Kuang-Pin
    Liang, Yu
    Zhang, Xing-Kui
    Li, Jun-Jun
    Guo, Jian-Hui
    Li, Li-Yan
    NEURAL REGENERATION RESEARCH, 2022, 17 (06) : 1299 - +
  • [37] The Neuroprotective Effect of Irisin in Ischemic Stroke
    Liu, Yaqiang
    Zhu, Chunhua
    Guo, Jiahui
    Chen, Yonghong
    Meng, Chaoyue
    FRONTIERS IN AGING NEUROSCIENCE, 2020, 12
  • [38] THE NEUROPROTECTIVE MECHANISM OF MICRORNA IN ISCHEMIC STROKE
    Wang, Shenglin
    Bao, Nana
    Cao, Xin
    Zhou, Jin
    Jiang, Guohui
    Wang, Li
    ACTA MEDICA MEDITERRANEA, 2022, 38 (03): : 1601 - 1602
  • [39] Neuroprotective strategies in acute ischemic stroke
    G. A. Ottonello
    G. Brusa
    V. Montano
    G. Regesta
    T. Regesta
    A. Seneghini
    The Italian Journal of Neurological Sciences, 1998, 19 (Suppl 1): : S25 - S25
  • [40] Systems neuroprotective mechanisms in ischemic stroke
    Liu S.Q.
    MCB Molecular and Cellular Biomechanics, 2019, 16 (02): : 75 - 85
12345