Novel substituted 4-aminomethylpiperidines as potent and selective human β3-agonists.: Part 2:: Arylethanolaminomethylpiperidines

被引：8
|
作者：
Steffan, RJ
Ashwell, MA
Solvibile, WR
Matelan, E
Largis, E
Han, S
Tillet, J
Mulvey, R
机构：
[1] Wyeth Ayerst Res, Chem Sci, Collegeville, PA 19426 USA
[2] Wyeth Ayerst Res, Cardiovasc Metab Dis, Collegeville, PA 19426 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 20期
关键词：
D O I：
10.1016/S0960-894X(02)00608-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and SAR of a series of beta(3) adrenoreceptor agonists based on a novel template derived from 4-aminomethylpiperidine coupled with a common pharmacophore, arylethylamine, is described. This combination led to the identification of human beta(3) adrenoreceptor agonists with in vivo activity in a transgenic mouse model. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2963 / 2967
页数：5
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