Thermal monitoring treatment nano-mixture based on Y2O3:Yb3+/Er3+ @SiO2/SiO2@Cu2S

Realizing accurate temperature measurement and control is very critical in photo-thermal therapy (PTT). Here, the temperature self-monitoring medicament-like photo-thermal nano-system of mixture Y2O3: Yb/Er@SiO2/SiO2@Cu2S was designed and the mixture of samples with excellent photo-thermal effect could reach 48 degrees C under 980 nm (1.0 W/cm(2)). The characteristics of optical temperature sensing were achieved by fluorescence intensity ratio (FIR) of green emissions from Er3+ in Y2O3: Yb/Er@SiO2 at different temperatures under 980 nm. It is proved that the FIR technology with the better precision than infrared thermal imager for real-time temperature detection in bio-tissue. In addition, the photo-thermal of Y2O3: Yb/Er@SiO2/SiO2@Cu2S nano-particles was proved by Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) ablation. The relevant results illustrate that the samples of Y2O3: Yb/Er@SiO2/SiO2@Cu2S has potential applications in the region of temperature self-monitoring photo-thermal therapy.