A convenient synthesis of tetrazolo[1,5-a]-α-cycloalkanones

被引：6
|
作者：
Shi, Yan
Robl, Jeffrey A.
Kennedy, Lawrence J.
Malley, Mary F.
机构：
[1] Bristol Myers Squibb Pharmaceut Res Inst, Dept Chem, Princeton, NJ 08543 USA
[2] Bristol Myers Squibb Pharmaceut Res Inst, Dept Solid State Chem, Princeton, NJ 08543 USA
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 04期
关键词：
D O I：
10.1016/j.tetlet.2006.11.125
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient synthesis of a series of tetrazolo[1,5-alpha]-alpha-cycloalkanones 4a-d with the carbonyl group attached at the tetrazole carbon is described. The sequence entails the formation of an exocyclic olefin at the alpha-methylene position and subsequent ozonolysis. The reactions proceed under mild conditions, and the tetrazole moiety is well tolerated. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：555 / 558
页数：4
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