In Silico Screening of Pyridine Derivatives as Potential DHFR Inhibitors for Anticancer Activity

被引：0
|
作者：
Nerkar, A. G. [1 ]
Ghone, S. A. [1 ]
Sareen, A. [1 ]
Mehta, A. [1 ]
Bhagat, S. A. [1 ]
Mohanraj, K. P. [1 ]
Thaker, A. K. [1 ]
机构：
[1] SVKMs NMIMS Univ, Sch Pharm & Technol Management, Dept Pharmaceut & Med Chem, Bombay 400056, Maharashtra, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2009年 / 21卷 / 09期
关键词：
In silico screening; Isoniazid; Schiff's bases; DHFR; ADME; Docking; DIHYDROFOLATE-REDUCTASE; BIOLOGICAL-ACTIVITY; DOCKING; DESIGN;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this paper, in silico screening prioritization of some pyridinyl Schiff bases (Schiff bases of isoniazid (INH)) as inhibitors of mammalian dihydrofolate reductase enzyme (DHFR) for anticancer activity, before actual synthesis of the molecules and anticancer evaluation are reported.
引用
收藏
页码：6975 / 6980
页数：6
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