Immunomodulatory effects of functionalised chalcones on pro-inflammatory cytokine release from lung epithelial cells

被引：10
|
作者：
Smith, Nicole Maria [1 ]
Soh, Pengkai
Asokananthan, Nithiananthan
Norret, Marck [1 ]
Stewart, Geoffrey A. [1 ]
Raston, Colin Llewellyn [1 ]
机构：
[1] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Ctr Strateg Nanofabricat, Crawley, WA 6009, Australia
来源：
NEW JOURNAL OF CHEMISTRY | 2009年 / 33卷 / 09期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
DERIVATIVES;
D O I：
10.1039/b909172f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chalcones, prepared in high yield in polyethylene glycol, M-w = 300 (PEG300), were screened for inhibition of the thrombin-mediated release of pro-inflammatory interleukin-6 (IL-6) and interleukin-8 (IL-8) from the A549 lung epithelial cell line. Several show significant down-regulation of these pro-inflammatory mediators in a dose-dependant manner with one exhibiting pro-inflammatory properties. Computational studies on selected chalcones revealed a detailed understanding of the structure, electron density and biological activity relationship.
引用
收藏
页码：1869 / 1873
页数：5
相关论文
共 50 条
  • [21] Studies on the interactions of Haemophilus parasuis with porcine epithelial tracheal cells: Limited role of LOS in apoptosis and pro-inflammatory cytokine release
    Bouchet, Benedicte
    Vanier, Ghyslaine
    Jacques, Mario
    Auger, Eliane
    Gottschalk, Marcelo
    MICROBIAL PATHOGENESIS, 2009, 46 (02) : 108 - 113
  • [22] EFFECTS OF CYCLOSPORINE A AND RAPAMYCIN ON PRO-INFLAMMATORY CYTOKINE PRODUCTION BY DENDRITIC CELLS IN VITRO
    Machcinska, Maja
    Bocian, Katarzyna
    Korczak-Kowalska, Grazyna
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2013, 28 : 411 - 411
  • [23] The phosphodiesterase type IV inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells in lung transplantation patients
    Murphy, Des M.
    Ward, Chris
    Forrest, Ian A.
    Pritchard, Gail
    Jones, Debbie
    Stovold, Rachel
    Fisher, Andrew J.
    Cawston, Tim E.
    Lordan, Jim L.
    Corris, Paul A.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2006, 25 (12): : 1436 - 1440
  • [24] Release of pro-inflammatory mediators and expression of pro-inflammatory adhesion molecules by endothelial progenitor cells
    Zhang, Y.
    Ingram, D. A.
    Mead, L. E.
    Prater, D. N.
    Murphy, M. P.
    Rehman, J.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2008, 56 (03) : 662 - 662
  • [25] DOSE-VOLUME EFFECTS IN THE RAT LUNG: RELATION TO PRO-INFLAMMATORY CYTOKINE EXPRESSION
    Gross, S.
    van Luijk, P.
    RADIOTHERAPY AND ONCOLOGY, 2009, 90 : S4 - S4
  • [26] Friction and Pro-Inflammatory Cytokine Production in Corneal Epithelial Cell Models
    Sawyer, W. Gregory
    Pitenis, Angela A.
    Uruena, Juan Manuel
    Hart, Samuel
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [27] Cell-Free Hemoglobin Elicits A Pro-Inflammatory Response In Lung Epithelial Cells
    Upchurch, C. P.
    Grove, B. S.
    Shaver, C. M.
    Janz, D. R.
    Ware, L. B.
    Bastarache, J. A.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 189
  • [28] Butyrate modulating effects on pro-inflammatory pathways in human intestinal epithelial cells
    Elce, A.
    Amato, F.
    Zarrilli, F.
    Calignano, A.
    Troncone, R.
    Castaldo, G.
    Canani, R. B.
    BENEFICIAL MICROBES, 2017, 8 (05) : 841 - 847
  • [29] The effects of pro-inflammatory cytokines on iron absorption by human intestinal epithelial cells
    Johnson, D. M.
    Sharp, P. A.
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2005, 64 : 91A - 91A
  • [30] The pro-inflammatory effects of particulate matter on epithelial cells are associated with elemental composition
    Shao, Jingyi
    Wheeler, Amanda J.
    Chen, Ling
    Strandberg, Bo
    Hinwood, Andrea
    Johnston, Fay H.
    Zosky, Graeme R.
    CHEMOSPHERE, 2018, 202 : 530 - 537
12345