Faecal microbiota transplantation for recurrent Clostridioides difficile infection: an Australian experience - effective, safe, yet room for improvement

被引：2
|
作者：
Chauhan, Ayushi [1 ]
Apostolov, Ross [1 ]
van Langenberg, Daniel [1 ,2 ]
Garg, Mayur [1 ,2 ,3 ,4 ]
机构：
[1] Eastern Hlth, Dept Gastroenterol, Melbourne, Vic, Australia
[2] Monash Univ, Eastern Hlth Clin Sch, Melbourne, Vic, Australia
[3] Royal Melbourne Hosp, Dept Gastroenterol & Hepatol, Melbourne, Vic, Australia
[4] Univ Melbourne, Dept Med, Melbourne, Vic, Australia
来源：
INTERNAL MEDICINE JOURNAL | 2021年 / 51卷 / 01期
关键词：
faecal microbiota transplantation; Clostridioides difficile; host− microbiota interaction; immune‐ mediated illness; ANA;
D O I：
10.1111/imj.15162
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Faecal microbiota transplantation (FMT) is reportedly effective and safe for the management of recurrent or refractory Clostridioides difficile infection (CDI), yet real-world data of outcomes of FMT in Australia are limited. In this series, FMT safely resulted in resolution of CDI in 19 patients with reduced healthcare utilisation after 25 FMT, but one patient was diagnosed with an anti-nuclear antibody-positive constitutional illness and Hashimoto thyroiditis following FMT. Further prospective evaluation of the utility of FMT earlier in CDI treatment algorithms to minimise cost and morbidity, and recipient follow up for immune-mediated conditions, is required.
引用
收藏
页码：106 / 110
页数：5
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