Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics

被引：77
|
作者：
Tang, Longguang [1 ,2 ]
Zhang, Fuwu [3 ]
Yu, Fei [1 ,2 ]
Sun, Wenjing [1 ,2 ]
Song, Menglin [1 ,2 ]
Chen, Xiaoyuan [3 ]
Zhang, Xianzhong [1 ,2 ]
Sun, Xiaolian [1 ,2 ]
机构：
[1] Xiamen Univ, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361005, Peoples R China
[2] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361005, Peoples R China
[3] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
来源：
BIOMATERIALS | 2017年 / 129卷
基金：
中国国家自然科学基金;
关键词：
Controlled assembly; Molecular nanoprobe; EPR effect; Multimodality imaging; Photothermal therapy; EFFECTIVE PHOTOTHERMAL AGENT; NANOMEDICINE; THERAPY; NANOCOMPOSITES; PERMEABILITY; CROCONIUM; MICELLE; SAFE; DYE;
D O I：
10.1016/j.biomaterials.2017.03.009
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention). These facilely synthesized molecular nanoprobes showed great clinical translation potential as a versatile theranostic agent. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：28 / 36
页数：9
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