COMPARISON OF DIFFERENT ASSESSMENT MODELS OF INSULIN RESISTANCE IN ROMANIAN OBESE PATIENTS

Insulin resistance is either an associated condition or is considered to be a predictor or pathogenic factor in various human pathological states such as type 2 diabetes mellitus, glucose intolerance, obesity, polycystic ovary syndrome, essential hypertension, metabolic syndrome and, more recently, atherosclerosis. The standard method for the evaluation of insulin resistance is the euglycemic hyperinsulinemic clamp technique. Direct determination of insulin sensitivity with the hyperinsulinemic-euglycemic clamp technique is laborious and impractical in large human studies. Since it is important to have accessible methods to estimate insulin secretion and sensitivity in the human body, mathematical models for the evaluation of insulin resistance have been developed. The main purpose of our study was to assess the relevance of different mathematical models for the evaluation of insulin resistance in the biochemical evaluation of a group of Romanian obese patients. Our results show that the homeostasis model assessment parameters (HOMA) and the Quicki test (Quantitative insulin sensitivity check index) vary significantly in correlation with both weight and glucose level in a group of Romanian subjects.