Chemical composition, protoscolicidal effects and acute toxicity of Pistacia atlantica Desf. fruit extract

被引：34

作者：

Mahmoudvand, Hossein ^{[1
]}

Kheirandish, Farnaz ^{[2
]}

Kia, Mehdi Ghasemi ^{[3
]}

Kareshk, Amir Tavakoli ^{[4
]}

Yarahmadi, Mohammad ^{[4
]}

机构：

[1] Kerman Univ Med Sci, Res Ctr Hydatid Dis Iran, Kerman, Iran

[2] Lorestan Univ Med Sci, Sch Med, Dept Med Parasitol & Mycol, Khorramabad, Iran

[3] Shahid Bahonar Univ, Dept Pathobiol, Fac Vet Med, Kerman, Iran

[4] Iran Univ Med Sci, Sch Med, Dept Med Mycol & Parasitol, Tehran, Iran

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 10期

关键词：

Hydatid cyst; scolicidal; toxicity; P; atlantica; ESSENTIAL OILS;

D O I：

10.1080/14786419.2015.1046868

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The present study was designed to evaluate the chemical composition and scolicidal effects of Pistacia atlantica Desf. extract against protoscoleces of hydatid cysts and its acute toxicity in mice model. Various concentrations of the methanolic extract (5-50mg/mL) were used for 10-60min. Viability of protoscoleces was confirmed using eosin exclusion test (0.1%). Acute toxicity was also determined in mice model. The main components were -myrcene (41.4%), -pinene (32.48%) and limonene (4.66%). Findings demonstrated that P. atlantica extract at the concentrations of 25 and 50mg/mL after 20 and 10min of exposure killed 100% protoscoleces. The LD50 of the intraperitoneal injection of the P. atlantica methanolic extract was 2.43g/kg and the maximum non-fatal dose was 1.66g/kg. Obtained results showed the potential of P. atlantica extract as a natural source with no significant toxicity for the production of new scolicidal agent to use in hydatid cyst surgery.

引用

页码：1208 / 1211

页数：4

共 50 条

[31] ASSESSING THE NATURAL DURABILITY OF NORTH ALGERIAN PISTACIA ATLANTICA DESF. TIMBER
Boudouaya, Manel
Benhassaini, Hachemi
Bendimered-Mouri, Fatima Zohra
Mothe, Frederic
Fournier, Meriem
BOIS ET FORETS DES TROPIQUES, 2015, (325) : 49 - 58
[32] Phytodiversity the group to Pistacia atlantica Desf. in the Saharan Atlas (Bechar -Algeria).
Abdelkrim, Benaradj
Mohamed, Bouazza
Hafidha, Boucherit
INTERNATIONAL CONFERENCE ON TECHNOLOGIES AND MATERIALS FOR RENEWABLE ENERGY, ENVIRONMENT AND SUSTAINABILITY -TMREES15, 2015, 74 : 258 - 264
[33] Impact of a gall-inducing aphid on Pistacia atlantica Desf. trees
J.-J. I. Martinez
Arthropod-Plant Interactions, 2008, 2 : 147 - 151
[34] Cellulosic and hemicellulosic fractions dosage of Pistacia atlantica Desf. subsp atlantica leaves in western Algeria
El Zerey-Belaskri, A.
Benhassaini, H.
Naimi, W.
Rahoui, S.
NATURAL PRODUCT RESEARCH, 2013, 27 (19) : 1757 - 1763
[35] Impact of a gall-inducing aphid on Pistacia atlantica Desf. trees
Martinez, J. -J. I.
ARTHROPOD-PLANT INTERACTIONS, 2008, 2 (03) : 147 - 151
[36] EVALUATION OF ANTIOXIDANT AND ANTIACETYLCHOLINESTERASE ACTIVITIES OF THE EXTRACTS OF PISTACIA ATLANTICA DESF. LEAVES
Peksel, Aysegul
Arisan-Atac, Inci
Yanardag, Refiye
JOURNAL OF FOOD BIOCHEMISTRY, 2010, 34 (03) : 451 - 476
[37] Radical scavenging and anti-acetylcholinesterase activities of aqueous extract of wild pistachio (Pistacia atlantica Desf.) leaves
Peksel, Aysegul
Arisan, Inci
Yanardag, Refiye
FOOD SCIENCE AND BIOTECHNOLOGY, 2013, 22 (02) : 515 - 522
[38] Using ensemble modeling to predict the current distribution of Pistacia atlantica Desf. in Algeria
Aloui, Massinissa
Neffar, Souad
Chenchouni, Haroun
SCIENCE OF NATURE, 2024, 111 (06):
[39] Essential oil from gum of Pistacia atlantica Desf.: Screening of antimicrobial activity
Ghalem, B. R.
Mohamed, B.
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2009, 3 (03): : 87 - 91
[40] The chemical composition of fruits of Pistacia adanlica Desf. subsp allantica from Algeria
Benhassaini, H.
Bendahmane, M.
Benchalgo, N.
CHEMISTRY OF NATURAL COMPOUNDS, 2007, 43 (02) : 121 - 124

← 1 2 3 4 5 →