Enantioselective reduction of ketones with borane catalyzed by tridentate amino alcohols derived from salicylaldehyde

被引：10
|
作者：
Lee, Dong-Sheng [1 ]
机构：
[1] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan
来源：
CHIRALITY | 2007年 / 19卷 / 02期
关键词：
tridentate chiral ligand; asymmetric reduction;
D O I：
10.1002/chir.20344
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
xIn the presence of tridentate chiral ligand 4e, 99% e.e. value was obtained by asymmetric reduction of ethyl benzoylacetate with borane in toluene at 25 degrees C. Various ligands and reaction conditions were investigated to develop a reasonable mechanism that explains the experimental outcomes.
引用
收藏
页码：148 / 151
页数：4
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