Integrated nanoplasmonic-nanofluidic biosensors with targeted delivery of analytes

被引:176
|
作者
Yanik, Ahmet Ali [1 ,2 ]
Huang, Min [1 ,2 ]
Artar, Alp [1 ,2 ]
Chang, Tsung-Yao [3 ]
Altug, Hatice [1 ,2 ]
机构
[1] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA
[2] Boston Univ, Photon Ctr, Boston, MA 02215 USA
[3] MIT, Dept Elect Engn, Cambridge, MA 02139 USA
关键词
bioMEMS; biosensors; microchannel flow; nanobiotechnology; nanofluidics; nanosensors; plasmonics; ARRAYS; LIGHT;
D O I
10.1063/1.3290633
中图分类号
O59 [应用物理学];
学科分类号
摘要
Performances of the biosensors are often limited by the depletion zones created around the sensing area which impede the effective analyte transport. To overcome this limitation, we propose and demonstrate a nanoplasmonic-nanofluidic sensor enabling targeted delivery of analytes to the sensor surface with dramatic improvements in mass transport efficiency. Our sensing platform is based on extraordinary light transmission effect in suspended plasmonic nanoholes. This scheme allows three-dimensional control of the fluidic flow by connecting separate layers of microfluidic channels through plasmonic/nanofluidic holes. To implement the proposed sensor platform, we also introduce a lift-off free nanofabrication method.
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页数:3
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