Malaria is probably the most serious health problem facing northern Amazonia, and isolated populations can benefit greatly from the knowledge of local resources which may effectively be used to control it. The results of an ethnobotanical survey of the plant species used in the treatment of malaria in the Brazilian State of Roraima are presented. Fieldwork was carried out amongst seven savanna-and forest-dwelling indigenous groups, and among the Luso-Brazilian population. Ninety-nine species, of 82 genera and 41 families, were identified as having been used for this purpose in the region. The results are discussed in the context of previously published information on anti-malarial plants of northern Latin America, which was analysed by a broad literature survey whose overall results are also presented here. Of the species collected in Roraima, only 24 appear previosly to have been reported as anti-malarials, although 49% of the represented genera are known to be used in this way elsewhere. The plants are currently undergoing laboratory screening for anti-malarial activity and toxicity.