Synthesis of photoactive p-azidotetrafluorophenylalanine containing peptide by solid-phase Fmoc methodology

被引：14

作者：

Redman, JE

Ghadiri, MR ^{[1
]}

机构：

[1] The Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] The Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA

[3] The Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 25期

关键词：

D O I：

10.1021/ol026998f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] N-Fmoc-L-p-azidotetrafluorophenylalanine was prepared from achiral starting materials using an acetamidomalonate synthesis and enzymatic resolution. A photoactive peptide containing this fluorinated residue could be assembled using solid-phase Fmoc chemistry.

引用

页码：4467 / 4469

页数：3

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