SOLID-PHASE SYNTHESIS OF A CYCLIC PEPTIDE USING FMOC CHEMISTRY

被引：64

作者：

MCMURRAY, JS

机构：

[1] Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 52期

关键词：

CYCLIC PEPTIDE; ON-RESIN CYCLIZATION; ALPHA-2,4-DIMETHOXYBENZYL (DMB) ESTERS; FMOC-GLU-ODMB; FMOC-ASP-ODMB;

D O I：

10.1016/0040-4039(91)80563-L

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using the Fmoc protection strategy of solid phase peptide synthesis, a 10 amino acid peptide was prepared and cyclized in a "head-to-tail" fashion while it was attached to the solid support. Cyclization was accomplished with either BOP or carbodiimide and the peptide was cleaved from the resin and purified using standard protocols.

引用

页码：7679 / 7682

页数：4

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