SOLID-PHASE SYNTHESIS OF A CYCLIC PEPTIDE USING FMOC CHEMISTRY

被引：64

作者：

MCMURRAY, JS

机构：

[1] Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 52期

关键词：

CYCLIC PEPTIDE; ON-RESIN CYCLIZATION; ALPHA-2,4-DIMETHOXYBENZYL (DMB) ESTERS; FMOC-GLU-ODMB; FMOC-ASP-ODMB;

D O I：

10.1016/0040-4039(91)80563-L

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using the Fmoc protection strategy of solid phase peptide synthesis, a 10 amino acid peptide was prepared and cyclized in a "head-to-tail" fashion while it was attached to the solid support. Cyclization was accomplished with either BOP or carbodiimide and the peptide was cleaved from the resin and purified using standard protocols.

引用

页码：7679 / 7682

页数：4

共 50 条

[31] Fmoc solid-phase synthesis of peptide thioesters using an intramolecular N,S-acyl shift
Ollivier, N
Behr, JB
El-Mahdi, O
Blanpain, A
Melnyk, O
ORGANIC LETTERS, 2005, 7 (13) : 2647 - 2650
[32] Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis
Biron, E
Kessler, H
JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (13): : 5183 - 5189
[33] Solid-phase synthesis of homodetic cyclic peptides from Fmoc-MeDbz-resin
Monaim, Shimaa A. H. Abdel
Acosta, Gerardo A.
Royo, Miriam
El-Faham, Ayman
de la Torre, Beatriz G.
Albericio, Fernando
TETRAHEDRON LETTERS, 2018, 59 (18) : 1779 - 1782
[34] New Fmoc pseudoisocytosine monomer for the synthesis of a bis-PNA molecule by automated solid-phase Fmoc chemistry
Neuner, P
Monaci, P
BIOCONJUGATE CHEMISTRY, 2002, 13 (03) : 676 - 678
[35] Efficient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis
Biron, Eric
Chatterjee, Jayanta
Kessler, Horst
UNDERSTANDING BIOLOGY USING PEPTIDES, 2006, : 102 - +
[36] Nsc and Fmoc Nα-amino protection for solid-phase peptide synthesis:: a parallel study
Carreño, C
Méndez, ME
Kim, YD
Kim, HJ
Kates, SA
Andreu, D
Albericio, F
JOURNAL OF PEPTIDE RESEARCH, 2000, 56 (02): : 63 - 69
[37] Solid-phase synthesis of cyclic peptide-DNA hybrids
Bleczinski, CF
Richert, C
ORGANIC LETTERS, 2000, 2 (12) : 1697 - 1700
[38] Solid-phase Synthesis of Tyrosine Cyclic DepsiPeptides from Fmoc-MeDbz-resin
Acosta Crespo, Gerardo
Murray, Laura Maria
Monaim, Shimaa A. H. Adbel
Royo, Miriam
El-Faham, Ayman
de la Torre, Beatriz G.
Albericio, Fernando
JOURNAL OF PEPTIDE SCIENCE, 2018, 24 : S91 - S91
[39] Fast conventional Fmoc solid-phase peptide synthesis: a comparative study of different activators
Chantell, Christina Ann
Onaiyekan, Michael Abayomi
Menakuru, Mahendra
JOURNAL OF PEPTIDE SCIENCE, 2012, 18 (02) : 88 - 91
[40] Protection of 3,4-dihydroxyphenylalanine (DOPA) for Fmoc solid-phase peptide synthesis
Hu, BH
Messersmith, PB
TETRAHEDRON LETTERS, 2000, 41 (31) : 5795 - 5798

← 1 2 3 4 5 →