Nanostructured waveguides for evanescent wave biosensors

被引：10
|
作者：
Popa, Ana Maria [1 ]
Wenger, Bernard [1 ]
Scolan, Emmanuel [1 ]
Voirin, Guy [1 ]
Heinzelmann, Harry [1 ]
Pugin, Raphael [1 ]
机构：
[1] CSEM Ctr Suisse Elect & Microtech SA, CH-2002 Neuchatel, Switzerland
来源：
APPLIED SURFACE SCIENCE | 2009年 / 256卷 / 03期
关键词：
Waveguide; Nanostructures; Block-copolymer lithography; Non-specific adsorption; Sensors; Biosensors; INTEGRATED OPTICAL CHIPS; SENSORS; SENSITIVITY;
D O I：
10.1016/j.apsusc.2009.04.042
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Nanostructuring waveguides bymeans of block-copolymer assisted lithography has as effect an increase in the total surface area. The non-specific adsorption of proteins on the nanostructured surfaces was monitored by wavelength-interrogated optical sensing and an increase in the sensitivity of the detection as compared to flat chips was observed. A model of the adsorption process confirmed the obtained experimental results and allowed the design of experimental approaches through which the detection sensitivity can be further improved. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：S12 / S17
页数：6
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