Effects of prenatal exposure to cigarette smoke on biochemical parameters of the blood of adult rat offspring

Prenatal cigarette smoke (CS) exposure during pregnancy is known to be associated with many severe prenatal and postnatal developmental abnormalities. The present study investigates serum biochemical parameters of adult rat offspring exposed prenatally to CS. Female white albino rats were exposed to CS during pregnancy 3 times/day (each 15 minutes) from gestational day 0 to parturition. Serum biochemical parameters were measured in adult male and female rat offspring (9-10 weeks in age) exposed prenatally to CS. Maternal CS exposure during gestation had no significant (P > 0.1) effect on serum biochemical parameters, including glucose, total proteins, albumins, globulins, albumins/globulins ratio, cholesterol, triglycerides, high density lipoproteins (HDL), low density lipoproteins (LDL), creatinine, bilirubin, urea, uric acid, alanine aminotransferase (ALT), alkaline phosphatase (ALP) in the blood of adult male and female rat offspring. However, prenatal CS exposure significantly ( P < 0.05) decreases serum aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT) in the blood of adult male and female rat offspring. Results demonstrated that CS exposure during gestation significantly decreases serum AST and GGT in the blood of adult male and female rat offspring.