Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization

被引：30
|
作者：
Dhiman, Shiv [1 ]
Saini, Hitesh Kumar [1 ]
Nandwana, Nitesh Kumar [1 ]
Kumar, Dalip [1 ]
Kumar, Anil [1 ]
机构：
[1] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India
来源：
RSC ADVANCES | 2016年 / 6卷 / 29期
关键词：
INTRAMOLECULAR DIRECT ARYLATION; ONE-POT SYNTHESIS; SODIUM-AZIDE; GEM-DIBROMOVINYLANILINES; ACRIDONE ALKALOIDS; CASCADE REACTIONS; ARYL AZIDES; AGENTS; METAL; INHIBITORS;
D O I：
10.1039/c6ra03798d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel regioselective synthesis of 2-aminoquinolines and 2-arylquinoline-3-carbonitriles is described via copper-mediated tandem reaction. Formation of substituted quinolines involves Knoevenagel condensation of ortho-bromobenzaldehyde with active methylene nitriles followed by copper-catalyzed reductive amination and intramolecular cyclization.
引用
收藏
页码：23987 / 23994
页数：8
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