Comparison of Gleason Scores in Specimens of Transrectal Prostate Needle Biopsy and Radical Prostatectomy

Comparison of Gleason Scores in Specimens of Transrectal Prostate Needle Biopsy and Radical Prostatectomy We investigated the correlation between biopsy and prostatectomy specimens, and evaluated the accuracy of treatment decision regarding to biopsy results in patients who have candidate to active-surveillance for localized prostate cancer (PC). Gleason score (GS) of the 118 patients who had undergone radical prostatectomy for PC after biopsy, were evaluated. Patients were cathegorized as low, intermediate and high-risk-PC regarding to rectal examination, serum PSA level and biopsy GS. Then, patients were reevaluated with prostatectomy GS (secondary-evaluation). Correlation and discorrelation in GS were determined in 52 and 66 (55.93%) patients, respectively. At biopsy, lower and higher grading was observed in 48 and 18 patients, respectively. Of 63 patients with low-risk-PC at primary-evaluation, 16 (25.39%) had intermediate-risk-PC at second-evaluation. Discorrelation was found in the rate of 56%, and it was more observed as low grading at biopsy. Finally, it should be considered that patients who will perform active-surveillance may be confronted with risk of undertreatment, with the assumption that 25% of patients with low-risk-PC may have actually intermediate-risk PC.