Mesalazine interstitial nephritis presenting as colitis ulcerosa exacerbation

被引:0
|
作者
Van Biervliet, S.
Raes, A.
Walle, J. Vande
Van Winckel, M.
Robberecht, E.
Praet, M.
机构
[1] Ghent Univ Hosp, Dept Paediat Gastroenterol, B-9000 Ghent, Belgium
[2] Ghent Univ Hosp, Dept Nephrol, B-9000 Ghent, Belgium
[3] Ghent Univ Hosp, Dept Pathol, B-9000 Ghent, Belgium
关键词
mesalazine; inflammatory bowel disease; interstitial nephritis;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Mesalazine is the first line treatment in paediatric inflammatory bowel disease (IBD). There are several reports in the literature about nephrotoxicity (1/150 treated patients), from renal insufficiency to reversible nephritis. It is currently advised to follow creatinin in patients treated with mesalazine during the first 5 years of treatment; however this may reveal the problem too late. As demonstrated in this paediatric case, a high degree of clinical suspicion is needed to diagnose the side effects before irreversible kidney damage occurs. Since the treatment of IBD exacerbation and mesalazine induced interstitial nephritis is based upon steroids, delayed diagnosis of the latter is at risk.
引用
收藏
页码:321 / 322
页数:2
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