Mechanism of citrinin-induced dysfunction of mitochondria .5. effect on the homeostasis of the reactive oxygen species

被引：0

作者：

Ribeiro, SMR ^{[1
]}

Chagas, GM ^{[1
]}

Campello, AP ^{[1
]}

Kluppel, MLW ^{[1
]}

机构：

[1] UNIV FED PARANA,DEPT BIOQUIM,BR-81531990 CURITIBA,PARANA,BRAZIL

来源：

CELL BIOCHEMISTRY AND FUNCTION | 1997年 / 15卷 / 03期

关键词：

citrinin; mycotoxin; rat liver mitochondria; superoxide dismutase; catalase; glutathione reductase; glutathione peroxidase; transhydrogenase; superoxide anion;

D O I：

10.1002/(SICI)1099-0844(199709)15:3<203::AID-CBF742>3.0.CO;2-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of citrinin in the maintenance of the homeostasis of the reactive oxygen species in rat liver cells were evaluated. Citrinin (CTN) modifies the antioxidant enzymatic defences of cells through the inhibition of GSSG-reductase and transhydrogenase. No effect was observed on GSH-peroxidase, catalase, glucose 6-phosphate and 6 phosphogluconate dehydrogenases, and superoxide dismutase. The mycotoxin increased the generation of reactive oxygen species, stimulating the production of the superoxide anion in the respiratory chain. The results suggest that oxidative stress is an important mechanism, side by side with other effects previously shown, in the establishment of the cytotoxicity and cellular death provoked by CTN in several tissues. (C) 1997 John Wiley & Sons, Ltd.

引用

页码：203 / 209

页数：7

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