Copper(II)-Catalyzed Direct Azidation of N-Acylated 8-Aminoquinolines by Remote C-H Activation

被引：52

作者：

Dou, Yandong ^{[1
]}

Xie, Zhenda ^{[1
]}

Sun, Zongguo ^{[1
]}

Fang, Hongli ^{[1
]}

Shen, Chao ^{[2
]}

Zhang, Pengfei ^{[3
]}

Zhu, Qing ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Key Lab Bioorgan Synth Zhejiang Prov, Hangzhou 310014, Zhejiang, Peoples R China

[2] Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou, Zhejiang, Peoples R China

[3] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou, Zhejiang, Peoples R China

来源：

CHEMCATCHEM | 2016年 / 8卷 / 23期

基金：

中国国家自然科学基金;

关键词：

azides; C-H activation; copper; nitrogen heterocycles; regioselectivity; STAUDINGER LIGATION; ARYL AZIDES; COMBINATION REACTIONS; MILD CONDITIONS; REAGENTS; CARBONYLATION; QUINOLINES; INHIBITORS; DISCOVERY; CATALYSIS;

D O I：

10.1002/cctc.201600874

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A simple and efficient copper(II)-catalyzed C5 azidation of N-acylated 8-aminoquinolines by remote C-H activation was developed. On the basis of this reaction, a series of new C5-azidated 8-amidequinolines were synthesized in moderate to good yields.

引用

页码：3570 / 3574

页数：5

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