Characterization of Polyphosphoesters by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

被引：16

作者：

Kaczorowska, Malgorzata A. ^{[1
]}

Cooper, Helen J. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Coll Life & Environm Sci, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2009年 / 20卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

ELECTRON-CAPTURE-DISSOCIATION; COLLISION-INDUCED DISSOCIATION; PAMAM DENDRIMER IONS; GENE DELIVERY; IN-VITRO; POLYMERS; DRUG; COPOLYMER; PEPTIDES;

D O I：

10.1016/j.jasms.2009.08.012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

FT-ICR mass spectrometry, together with collision-induced dissociation and electron capture dissociation, has been used to characterize the polyphosphoester poly[1,4-bis(hydroxyethyl) terephthalate-alt-ethyloxyphosphate] and its degradation products. Three degradation pathways were elucidated: hydrolysis of the phosphate-[1,4-bis(hydroxyethyl)terephthalate] bonds; hydrolysis of the phosphate- ethoxy bonds; and hydrolysis of the ethyl-terephthalate bonds. The dominant degradation reactions were those that involved the phosphate groups. This work constitutes the first application of mass spectrometry to the characterization of polyphosphoesters and demonstrates the suitability of high mass accuracy FT-ICR mass spectrometry, with CID and ECD, for the structural analysis of polyphosphoesters and their degradation products. (J Am Soc Mass Spectrom2009, 20, 2238-2247) (C) 2009 American Society for Mass Spectrometry

引用

页码：2238 / 2247

页数：10

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