Biosynthesis of alkyne-containing natural products

被引：38

作者：

Li, Xinyang ^{[1
]}

Lv, Jian-Ming ^{[2
]}

Hu, Dan ^{[2
]}

Abe, Ikuro ^{[1
,3
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Peoples R China

[3] Univ Tokyo, Collaborat Res Inst Innovat Microbiol, Bunkyo Ku, Yayoi 1-1-1, Tokyo 1138657, Japan

来源：

RSC CHEMICAL BIOLOGY | 2021年 / 2卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

FATTY-ACID SYNTHESIS; GENE-CLUSTER; POLYKETIDE SYNTHASE; ACYLTRANSFERASE DOMAIN; DYNEMICIN ENEDIYNE; COA DESATURASE; TRIPLE BOND; ENZYME; CHEMISTRY; MECHANISM;

D O I：

10.1039/d0cb00190b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alkyne-containing natural products are important molecules that are widely distributed in microbes and plants. Inspired by the advantages of acetylenic products used in the fields of medicinal chemistry, organic synthesis and material science, great efforts have focused on discovering the biosynthetic enzymes and pathways for alkyne formation. Here, we summarize the biosyntheses of alkyne-containing natural products and introduce de novo biosynthetic strategies for alkyne-tagged compound production.

引用

页码：166 / 180

页数：15

共 50 条

[41] Radical SAM enzymes in the biosynthesis of sugar-containing natural products
Ruszczycky, Mark W.
Ogasawara, Yasushi
Liu, Hung-wen
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2012, 1824 (11): : 1231 - 1244
[42] Radical SAM enzymes in the biosynthesis of sugar-containing natural products
Liu, Hung-Wen
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
[43] Uncovering the paradigm for biosynthesis of 7-deazapurine containing natural products
Bandarian, Vahe
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
[44] Radical SAM enzymes in the biosynthesis of sugar-containing natural products
Liu, Hung-Wen
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
[45] Synthesis and Evaluation of Cytocompatible Alkyne-Containing Poly(β-amino ester)-Based Hydrogels Functionalized via Click Reaction
Yao, Ke
Gong, Guangming
Fu, Zexi
Wang, Yuqing
Zhang, Luzhong
Li, Guicai
Yang, Yumin
ACS MACRO LETTERS, 2020, 9 (09) : 1391 - 1397
[46] An Alkyne-Containing Isoprenoid Analogue Based on a Farnesyl Diphosphate Scaffold Is a Biologically Functional Universal Probe for Proteomic Analysis
Auger, Shelby A.
Pedersen, Jodi S.
Maity, Sanjay
Sprague-Getsy, Andrea M.
Lorimer, Ellen L.
Koehn, Olivia J.
Krauklis, Steven A.
Berns, Brenna
Murphy, Katherine M.
Hussain, Jamal
Thao, Pa
Bernhagen, Kaitlyn
Justyna, Katarzyna
Sundaresan, Anjana P.
Mckim, Daniel B.
Williams, Carol L.
Hougland, James L.
Li, Ling
Distefano, Mark D.
BIOCHEMISTRY, 2024, 64 (01) : 138 - 155
[47] Synthesis and polymerization of alkyne-containing monomers: Towards dendronized polymers via combination of NMRP and click-chemistry
Fleischmann, Sven
Messerschmidt, Martin
Voit, Brigitte I.
Hawker, Craig J.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
[48] Singlet Oxygen Involvement in the Photochemical Reaction of C60 and Amines. Synthesis of an Alkyne-Containing Fullerene
Department of Chemistry, University of California, Los Angeles, CA 90095-1569, United States
J Phys Chem A, 36 (7244-7247):
[49] Biosynthesis of para-Cyclophane-Containing Hirsutellone Family of Fungal Natural Products
Ohashi, Masao
Kakule, Thomas B.
Tang, Man-Cheng
Jamieson, Cooper S.
Liu, Mengting
Zhao, Yi-Lei
Houk, Kendall N.
Tang, Yi
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 143 (15) : 5605 - 5609
[50] Biosynthesis of para-Cyclophane-Containing Hirsutellone Family of Fungal Natural Products
Ohashi, Masao
Kakule, Thomas B.
Tang, Man-Cheng
Jamieson, Cooper S.
Liu, Mengting
Zhao, Yi-Lei
Houk, Kendall N.
Tang, Yi
Journal of the American Chemical Society, 2021, 143 (15): : 5605 - 5609

← 1 2 3 4 5 →