HIV-I tat interaction with Dicer: requirement for RNA

被引：79
|
作者：
Bennasser, Yamina [1 ]
Jeang, Kuan-Teh [1 ]
机构：
[1] NIAID, Mol Virol Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA
来源：
RETROVIROLOGY | 2006年 / 3卷 / 1期
关键词：
D O I：
10.1186/1742-4690-3-95
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Dicer is an RNase III which processes two classes of cellular small RNAs: the microRNAs (miRNA) and short interfering RNAs (siRNA). Previously, we observed that over-expressed HIV-1 Tat protein can suppress the processing of small RNAs inside cells. Here, we have investigated the requirements for Tat interaction with Dicer. We report that Tat-Dicer interaction depends on RNA, requires the helicase domain of Dicer, and is independent of Tat's transactivation domain.
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页数：6
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