Cardiac Mineralocorticoid Receptor and the Na+/H+ Exchanger: Spilling the Beans

被引：9

作者：

Ennis, Irene Lucia ^{[1
]}

Perez, Nestor Gustavo ^{[1
]}

机构：

[1] Univ Nacl La Plata, Fac Ciencias Med Plata, Ctr Invest Cardiovasc Dr Horacio E Cingolani, La Plata, Argentina

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 7卷

关键词：

aldosterone; mineralocorticoid receptor (MR); myocardial stretch; heart failure; NHE1; oxidative stress; LEFT-VENTRICULAR DYSFUNCTION; FINERENONE VS. EPLERENONE; CHRONIC HEART-FAILURE; SLOW FORCE RESPONSE; ANGIOTENSIN-II; SIGNALING PATHWAY; ALDOSTERONE; RAT; ACTIVATION; SPIRONOLACTONE;

D O I：

10.3389/fcvm.2020.614279

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current evidence reveals that cardiac mineralocorticoid receptor (MR) activation following myocardial stretch plays an important physiological role in adapting developed force to sudden changes in hemodynamic conditions. Its underlying mechanism involves a previously unknown nongenomic effect of the MR that triggers redox-mediated Na+/H+ exchanger (NHE1) activation, intracellular Na+ accumulation, and a consequent increase in Ca2+ transient amplitude through reverse Na+/Ca2+ exchange. However, clinical evidence assigns a detrimental role to MR activation in the pathogenesis of severe cardiac diseases such as congestive heart failure. This mini review is meant to present and briefly discuss some recent discoveries about locally triggered cardiac MR signals with the objective of shedding some light on its physiological but potentially pathological consequences in the heart.

引用

页数：7

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