Protease-catalyzed synthesis of new hydrophobic dipeptides containing non-proteinogenic amino acids

被引：17

作者：

Krix, G

Eichhorn, U

Jakubke, HD

Kula, MR

机构：

[1] UNIV DUSSELDORF, INST ENZYMTECHNOL, D-52404 JULICH, GERMANY

[2] UNIV LEIPZIG, FAK BIOWISS PHARM, D-7010 LEIPZIG, GERMANY

[3] UNIV LEIPZIG, FAK BIOWISS PHARM & PSYCHOL, INST BIOCHEM, D-7010 LEIPZIG, GERMANY

来源：

ENZYME AND MICROBIAL TECHNOLOGY | 1997年 / 21卷 / 04期

关键词：

peptide synthesis; enzymatic chymotrypsin; thermolysin; tertiary leucine; neopentylglycin;

D O I：

10.1016/S0141-0229(97)00037-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Several dipeptides containing nonproteinogenic amino acids (especially L-tertiary leucine or L-neopentyglycine) were synthesized enzymatically. Thermolysin was used in solid-to-solid conversions in an equilibrium-controlled reaction while alpha-chymotrypsin was applied in kinetically controlled synthesis. The dipeptide Z-Npg-Npg-NH2 could be obtained using a protease mixture from Streptomyces. The active enzyme has not yet been purified. (C) 1997 Elsevier Science Inc.

引用

页码：252 / 257

页数：6

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