Synthesis and ion channel formation of novel cyclic peptides containing a non-natural amino acid

被引：16
|
作者：
Ishida, H
Donowaki, K
Inoue, Y
Qi, Z
Sokabe, M
机构：
[1] OSAKA UNIV, FAC ENGN, DEPT MOL CHEM, SUITA, OSAKA 565, JAPAN
[2] NAGOYA UNIV, SCH MED, DEPT PHYSIOL, SHOWA KU, NAGOYA, AICHI 466, JAPAN
来源：
CHEMISTRY LETTERS | 1997年 / 09期
关键词：
D O I：
10.1246/cl.1997.953
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of novel cyclic peptides possessing an alternate natural/non-natural amino acid sequence were prepared from L-alanine and 5-(N-acylamino)-3-aminobenzoic acid with a long acyl chain. Upon examination by the voltage clamp method, membranes composed of the synthetic cyclic peptides with varying ring sizes and side-chain lengths were found to form cation selective channels with a conductance of ca. 9 pS in aqueous KCl (500 mM).
引用
收藏
页码：953 / 954
页数：2
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