mRNA Vaccines against Flaviviruses

被引：29
|
作者：
Wollner, Clayton J. [1 ]
Richner, Justin M. [1 ]
机构：
[1] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA
来源：
VACCINES | 2021年 / 9卷 / 02期
关键词：
flavivirus; mRNA vaccines; Dengue; Zika; tick-borne encephalitis;
D O I：
10.3390/vaccines9020148
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Numerous vaccines have now been developed using the mRNA platform. In this approach, mRNA coding for a viral antigen is in vitro synthesized and injected into the host leading to exogenous protein expression and robust immune responses. Vaccines can be rapidly developed utilizing the mRNA platform in the face of emerging pandemics. Additionally, the mRNA coding region can be easily manipulated to test novel hypotheses in order to combat viral infections which have remained refractory to traditional vaccine approaches. Flaviviruses are a diverse family of viruses that cause widespread disease and have pandemic potential. In this review, we discuss the mRNA vaccines which have been developed against diverse flaviviruses.
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页码：1 / 13
页数：13
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