Advanced strategies for development of vaccines against human bacterial pathogens

被引：6

作者：

Sharma, Abhinay ^{[1
,3
,5
]}

Sanduja, Pooja ^{[1
]}

Anand, Aparna ^{[5
]}

Mahajan, Pooja ^{[1
]}

Guzman, Carlos A. ^{[3
]}

Yadav, Puja ^{[4
]}

Awasthi, Amit ^{[6
]}

Hanski, Emanuel ^{[5
]}

Dua, Meenakshi ^{[2
]}

Johri, Atul Kumar ^{[1
]}

机构：

[1] Jawaharlal Nehru Univ, Sch Life Sci, Aruna Asaf Ali Marg, New Delhi 110067, India

[2] Jawaharlal Nehru Univ, Sch Environm Sci, Aruna Asaf Ali Marg, New Delhi 110067, India

[3] Helmholtz Ctr Infect Res, Dept Vaccinol, Inhoffenstr 7, D-38124 Braunschweig, Germany

[4] Cent Univ Haryana, Dept Microbiol, Mahendragarh, Harayana, India

[5] Hebrew Univ Jerusalem, Fac Med, Israel Canada IMRIC, Dept Microbiol & Mol Genet,Inst Med Res, IL-9112102 Jerusalem, Israel

[6] Translat Hlth Sci & Technol Inst, NCR Biotech Sci Cluster, Faridabad Gurgaon Expressway,POB 04,3rd Milestone, Faridabad 121001, Haryana, India

来源：

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 2021年 / 37卷 / 04期

关键词：

Genomics; Human pathogens; Protein microarray; Proteomics; Reverse vaccinology; Vaccine; EXPRESSION LIBRARY IMMUNIZATION; SIGNATURE-TAGGED MUTAGENESIS; GROUP-A STREPTOCOCCUS; CRYPTOSPORIDIUM-PARVUM; ANTIGENOME TECHNOLOGY; PROTEOMIC ANALYSIS; GENOME SEQUENCE; VIRULENCE GENES; HIGH-THROUGHPUT; PROTEIN;

D O I：

10.1007/s11274-021-03021-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Infectious diseases are one of the main grounds of death and disabilities in human beings globally. Lack of effective treatment and immunization for many deadly infectious diseases and emerging drug resistance in pathogens underlines the need to either develop new vaccines or sufficiently improve the effectiveness of currently available drugs and vaccines. In this review, we discuss the application of advanced tools like bioinformatics, genomics, proteomics and associated techniques for a rational vaccine design.

引用

页数：11

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