Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies

被引：0

作者：

Otton, Hannah J. ^{[1
]}

Janssen, Ariane ^{[1
]}

Wyllie, David J. A. ^{[1
]}

机构：

[1] Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷

关键词：

ethanol; gamma-aminobutyric acid type A receptor (GABA(A)R); glutamate; glycine; malt whisky; N-methyl-D-aspartate receptor (NMDAR); XENOPUS-LAEVIS OOCYTES; NMDA RECEPTORS; ETHANOL; SUBTYPES; ALCOHOL;

D O I：

10.1042/BST0371423

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NMDARs (N-methyl-D-aspartate receptors) are considered to be a target for the inhibitory actions of ethanol. While profound inhibition of both native and recombinant NMDARs can be observed following the application of high concentrations of ethanol the levels of inhibition seen with lower concentrations of ethanol are more modest. Here, we report the effects of inhibiting NMDAR-mediated responses with ethanol concentrations that are experienced during the social consumption of alcohol comparing levels of inhibition seen with 'pure' ethanol with those produced by ethanol contained in three popular single malt whiskies.

引用

页码：1423 / 1425

页数：3

共 50 条

[31] Characteristics of internalization of NMDA-type GluRs with antibodies to GluN1 and GluN2B
Takahashi, Yukitoshi
Nishimura, Shigeko
Takao, Emiko
Kasai, Risa
Enokida, Kaoru
Ida, Kuniko
Fukuoka, Masataka
Koike, Takayoshi
Omatsu, Hiroo
Yamaguchi, Tokito
Takano, Shiho
Yoshida, Tomoyuki
Mori, Hisashi
JOURNAL OF NEUROIMMUNOLOGY, 2020, 349
[32] Effects of rhynchophylline on GluN1 and GluN2B expressions in primary cultured hippocampal neurons
He, Yan
Zeng, Sheng-Ya
Zhou, Shi-Wen
Qian, Gui-Sheng
Peng, Kang
Mo, Zhi-Xian
Zhou, Ji-Yin
FITOTERAPIA, 2014, 98 : 166 - 173
[33] GluN2A and GluN2B N-Methyl-D-Aspartate Receptor (NMDARs) Subunits: Their Roles and Therapeutic Antagonists in Neurological Diseases
Ladagu, Amany Digal
Olopade, Funmilayo Eniola
Adejare, Adeboye
Olopade, James Olukayode
PHARMACEUTICALS, 2023, 16 (11)
[34] Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N-methyl-D-aspartate Receptor Function and Neuronal Excitotoxicity
Zhou, Xianju
Ding, Qi
Chen, Zhuoyou
Yun, Huifang
Wang, Hongbing
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (33) : 24151 - 24159
[35] The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca2+ Permeability of GluN1/GluN2A N-Methyl-D-Aspartate Receptors
Perszyk, Riley E.
Zheng, Zhaoshi
Banke, Tue G.
Zhang, Jing
Xie, Lingling
McDaniel, Miranda J.
Katzman, Brooke M.
Pelly, Stephen C.
Yuan, Hongjie
Liotta, Dennis C.
Traynelis, Stephen F.
MOLECULAR PHARMACOLOGY, 2021, 99 (05) : 399 - 411
[36] Semi-quantitative analyses of antibodies to N-methyl-D-aspartate type glutamate receptor subunits (GluN2B & GluN1) in the clinical course of Rasmussen syndrome
Fukuyama, Tetsuhiro
Takahashi, Yukitoshi
Kubota, Yuko
Mogami, Yukiko
Imai, Katsumi
Kondo, Yoshiyuki
Sakuma, Hiroshi
Tominaga, Koji
Oguni, Hirokazu
Nishimura, Shigeko
EPILEPSY RESEARCH, 2015, 113 : 34 - 43
[37] Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits
O'Leary, Timothy
Wyllie, David J. A.
BIOCHEMICAL SOCIETY TRANSACTIONS, 2009, 37 : 1347 - 1354
[38] Properties of Triheteromeric N-Methyl-D-Aspartate Receptors Containing Two Distinct GluN1 Isoforms
Yi, Feng
Zachariassen, Linda G.
Dorsett, Katherine N.
Hansen, Kasper B.
MOLECULAR PHARMACOLOGY, 2018, 93 (05) : 453 - 467
[39] GluN2A and GluN2B NMDA receptors use distinct allosteric routes
Tian, Meilin
Stroebel, David
Piot, Laura
David, Melissa
Ye, Shixin
Paoletti, Pierre
NATURE COMMUNICATIONS, 2021, 12 (01)
[40] GluN2A and GluN2B NMDA receptors use distinct allosteric routes
Meilin Tian
David Stroebel
Laura Piot
Mélissa David
Shixin Ye
Pierre Paoletti
Nature Communications, 12

← 1 2 3 4 5 →