An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals

被引:80
|
作者
Micallef, M. A. [1 ]
Munro, I. A. [1 ]
Garg, M. L. [1 ,2 ]
机构
[1] Univ Newcastle, Nutraceut Res Grp, Sch Biomed Sci, Callaghan, NSW 2308, Australia
[2] John Hunter Hosp, Hunter Med Res Inst, New Lambton, NSW, Australia
关键词
C-reactive protein; omega-3 fatty acids; cardiovascular disease; inflammation; CARDIOVASCULAR-DISEASE; SERUM CONCENTRATIONS; MARKERS; OMEGA-3-FATTY-ACIDS; FISH;
D O I
10.1038/ejcn.2009.20
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
High sensitivity C-reactive protein (hs-CRP) is a marker of low-grade sustained inflammation. Omega-3 (n-3) fatty acids have anti-inflammatory properties and are associated with reduced cardiovascular disease (CVD) risk. The aim of this study was to investigate whether plasma n-3 fatty acid concentration is related to hs-CRP concentration. A total of 124 free-living adults, were divided into tertiles of plasma hs-CRP (<1.0, 1.0-3.0 and >3.0 mg/l). Body composition and anthropometric measurements were recorded. Hs-CRP was analysed using immunoassays and fatty acids were measured by gas chromatography. Plasma hs-CRP concentration was negatively correlated with total n-3 fatty acids (P=0.05), eicosapentaenoic acid (EPA; P=0.002) and docosapentaenoic acid (DPA; P=0.01). The highest hs-CRP tertile (>3.0 mg/l) had significantly lower concentrations of total n-3 fatty acids, EPA and DPA, when compared with the other tertiles (P<0.05). This study provides evidence that in healthy individuals, plasma n-3 fatty acid concentration is inversely related to hs-CRP concentration, a surrogate marker of CVD risk. European Journal of Clinical Nutrition (2009) 63, 1154-1156; doi:10.1038/ejcn.2009.20; published online 8 April 2009
引用
收藏
页码:1154 / 1156
页数:3
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