New treatments for methicillin-resistant Staphylococcus aureus

被引:40
|
作者
Stryjewski, Martin E. [1 ,2 ]
Corey, G. Ralph [2 ,3 ]
机构
[1] CEMIC, Dept Med, RA-1425 Buenos Aires, DF, Argentina
[2] Duke Clin Res Inst, Div Infect Dis, Durham, NC USA
[3] Duke Univ, Med Ctr, Durham, NC USA
关键词
investigational drugs; methicillin-resistant Staphylococcus aureus; new therapies; treatment; SKIN-STRUCTURE INFECTIONS; BLOOD-STREAM INFECTIONS; IN-VITRO ACTIVITY; DOUBLE-BLIND; COMPLICATED SKIN; LINEZOLID RESISTANCE; WEEKLY DALBAVANCIN; VANCOMYCIN; DAPTOMYCIN; THERAPY;
D O I
10.1097/MCC.0b013e32832f0a74
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Purpose of review Methicillin-resistant Staphylococcus aureus (MRSA) is a dynamic pathogen. Rates of MRSA are increasing worldwide. In some centers, MRSA is becoming less susceptible to vancomycin, and these strains have been associated with worse clinical outcomes. Intermediate or fully resistant vancomycin strains of MRSA have emerged clinically, whereas MRSA acquired in the community has become epidemic. The purpose of this manuscript is to provide clinicians with an evidence-based review on new treatments for MRSA. Recent findings Linezolid, daptomycin and tigecycline have been approved during the last decade to treat infections due to MRSA. Although these agents are extremely valuable in the fight against MRSA, each one has limitations. New lypoglycopeptides (telavancin, dalbavancin and oritavancin) are in advanced phase of clinical development. Similarly, new broad-spectrum cephalosporins active against MRSA (e.g. ceftobiprole and ceftaroline) and a new dihydrofolate reductase inhibitor (iclaprim) are in or have completed phase 3 studies. Summary Here, we review the most relevant information on new drugs to treat MRSA. New studies with available agents and upcoming studies with investigational drugs will help to better understand the role of each compound in the treatment of patients infected with MRSA and assist the clinician in keeping pace with this challenging pathogen.
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页码:403 / 412
页数:10
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