Recursive Test of Hardy-Weinberg Equilibrium in Tetraploids

被引：11
|
作者：
Sun, Lidan [1 ,2 ]
Gan, Jingwen [1 ,3 ]
Jiang, Libo [1 ,3 ]
Wu, Rongling [1 ,3 ,4 ,5 ]
机构：
[1] Beijing Forestry Univ, Beijing Adv Innovat Ctr Tree Breeding Mol Design, Beijing 100083, Peoples R China
[2] Beijing Forestry Univ, Natl Engn Res Ctr Floriculture, Beijing Lab Urban & Rural Ecol Environm, Sch Landscape Architecture,Beijing Key Lab Orname, Beijing 100083, Peoples R China
[3] Beijing Forestry Univ, Coll Biol Sci & Technol, Ctr Computat Biol, Beijing 100083, Peoples R China
[4] Penn State Univ, Ctr Stat Genet, Dept Publ Hlth Sci, Hershey, PA 17033 USA
[5] Penn State Univ, Ctr Stat Genet, Dept Stat, Hershey, PA 17033 USA
来源：
TRENDS IN GENETICS | 2021年 / 37卷 / 06期
基金：
中国国家自然科学基金;
关键词：
GENOTYPING ERRORS; DOUBLE REDUCTION; GENOME-WIDE; PROPORTIONS; DISEQUILIBRIUM; ASSOCIATION; SEGREGATION; POLYPLOIDY; DEVIATIONS; GENETICS;
D O I：
10.1016/j.tig.2020.11.006
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Testing for deviations from Hardy-Weinberg equilibrium (HWE) can provide fundamental information about genetic variation and evolutionary processes in natural populations. In contrast to diploids, where genotype frequencies remain constant after a single episode of random mating, polyploids, characterized by polysomic inheritance, approach HWE gradually. Here, we mathematically show the asymptotic trajectory of tetraploid equilibrium from any initial genotype frequencies. We formulate a statistical framework to test and estimate the degree of deviation from HWE at individual loci in allotetraploids and autotetraploids. Knowledge about HWE test fills an important gap in population genetic studies of tetraploids related to their evolution and ecology.
引用
收藏
页码：504 / 513
页数：10
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