Retinal vascular caliber associated with cardiac and renal target organ damage in never-treated hypertensive patients

ObjectiveThe aim of this study was to assess the relationship between retinal vascular caliber and target organ damage in HT patients. MethodsData were collected on cardiac, renal, vascular, and retinal variables in 88 consecutive never-treated HT subjects. Retinal vascular calibers were measured from fundus photographs by using a semi-automated computer-assisted program and summarized as CRAE and CRVE. ResultsMean CRAE and CRVE were significantly lower in patients with left ventricular hypertrophy (left ventricular mass 110g/m(2) for women, 125g/m(2) for men) than in those with normal left ventricular (CRAE: 129.43.7 vs 138.2 +/- 2.3m; P=.04; CRVE: 195.6 +/- 4.4 vs 209.8 +/- 2.7m; P=.008). CRAE and CRVE were negatively correlated with urinary albumin excretion (+/- SE=-15.4 +/- 3.2, P<.0001 and +/- SE=-11.9 +/- 4.4, P=.001, respectively) but were not correlated with estimated glomerular filtration rate (P=.21 and P=.75, respectively), carotid-to-femoral pulse wave velocity (P=.24 and P=.14), or carotid augmentation index (P=.43 and P=.16). ConclusionIn never-treated HT patients, reduced CRAE and CRVE were associated with cardiac and renal preclinical damage, ie, left ventricular hypertrophy and albuminuria, but not estimated glomerular filtration rate or vascular stiffness.