Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes

被引：44

作者：

Offiong, OE ^{[1
]}

Nfor, E

Ayi, AA

Martelli, S

机构：

[1] Univ Calabar, Dept Chem, Calabar, Nigeria

[2] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy

来源：

TRANSITION METAL CHEMISTRY | 2000年 / 25卷 / 04期

关键词：

D O I：

10.1023/A:1007055304150

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Novel Pd-II and Pt-II complexes of substituted o-hydroxyacetophenone-glycine have been synthesized, and characterized by conductivity measurements, i.r., electronic and H-1-n.m.r. spectra. The spectral data indicate that the ligands are monobasic bidentate, coordinating through imino nitrogen and the carboxylate group. A four coordinate square planar configuration has been proposed for all the complexes. The ligands, as well as their Pd-II and Pt-II complexes, exhibit potent cytotoxic activity against Ehrlich ascites tumour cells in vitro, but appear to be more active in vivo.

引用

页码：369 / 373

页数：5

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