Total Synthesis of gem-Difluoromethylenated Analogues of Pironetin

被引：15

作者：

Lin, Jing ^{[1
]}

Yue, Xuyi ^{[2
]}

Huang, Peng ^{[3
]}

Cui, Daxiang ^{[3
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[3] Shanghai Jiao Tong Univ, Inst Micro Nano Sci & Technol, Shanghai 200240, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2010年 / 02期

基金：

中国国家自然科学基金;

关键词：

pironetin; alpha; beta-unsaturated delta-lactones; gem-difluoromethylenated analogues; CHIRAL BUILDING-BLOCK; ENANTIOSELECTIVE SYNTHESIS; (-)-PIRONETIN; (-)-PA-48153C; DERIVATIVES; EFFICIENT; TUBULIN; NK10958;

D O I：

10.1055/s-0029-1217099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The straightforward synthesis of four gem-difluoromethylenated analogues of pironetin is described. Our synthesis features the efficient construction of the key intermediates through the indium-mediated gem-difluoropropargylation of aldehydes with the fluorine-containing building block.

引用

页码：267 / 275

页数：9

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