Reduction of aberrant crypt foci by ingestion of polydextrose in the rat colorectum

被引：10
|
作者：
Ishizuka, S [1 ]
Nagai, T
Hara, H
机构：
[1] Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Sapporo, Hokkaido 0608589, Japan
[2] Hokkaido Univ, Coll Med Technol, Sapporo, Hokkaido 0600812, Japan
来源：
NUTRITION RESEARCH | 2003年 / 23卷 / 01期
关键词：
polydextrose; aberrant crypts; 1,2-dimethylhydrazine;
D O I：
10.1016/S0271-5317(02)00485-2
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
To investigate the effect of dietary polydextrose on development of aberrant crypt foci (ACF), we fed rats with polydextrose-containing diet in various timing before or after 1,2-dimethythydrazine (DMH) injection and measured ACF parameters. Every parameter for ACF was significantly reduced in the rats fed polydextrose from day 7 before DMH injection than in the fiber-free diet fed rats. This study shows that ingestion of polydextrose has protective effect on ACF especially in the rectum and the timing of dietary treatment is critical for inhibition of ACF development. (C) 2003 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：117 / 122
页数：6
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