Reduction of aberrant crypt foci by ingestion of polydextrose in the rat colorectum

To investigate the effect of dietary polydextrose on development of aberrant crypt foci (ACF), we fed rats with polydextrose-containing diet in various timing before or after 1,2-dimethythydrazine (DMH) injection and measured ACF parameters. Every parameter for ACF was significantly reduced in the rats fed polydextrose from day 7 before DMH injection than in the fiber-free diet fed rats. This study shows that ingestion of polydextrose has protective effect on ACF especially in the rectum and the timing of dietary treatment is critical for inhibition of ACF development. (C) 2003 Elsevier Science Inc. All rights reserved.