Effect of platelet-rich plasma on orthodontic tooth movement in dogs

Objectives: To evaluate the effect of platelet-rich plasma (PRP) on the rate of orthodontic tooth movement. Methods: The sample comprised six skeletally mature male mongrel dogs. The maxillary second premolar in each dog was extracted bilaterally. PRP was prepared and injected around the first premolar in one randomly selected maxillary quadrant while the other quadrant served as the control. Coil springs (150 g) were used to distalize the first premolars for 63 days using TAD as anchorage. Results: Total maxillary tooth movement was significantly faster on the experimental than on the control side. Conclusion: Local injection of PRP in the present animal study resulted in accelerated orthodontic tooth movement with no obvious clinical or microscopic side effects.