Intramolecular [3+2]-cycloaddition of salicylaldehydes-based cyclic azomethine imines to access novel tetrahydrochromeno[4,3-c] pyrazolo[1,2-a]pyrazol-9-ones

被引：3

作者：

Wu, Mei-Chun ^{[1
,2
]}

Xia, Peng-Ju ^{[1
]}

Hu, Yuan-Zhuo ^{[1
]}

Ye, Zhi-Peng ^{[1
]}

Chen, Kai ^{[1
]}

Xiang, Hao-Yue ^{[1
]}

Yang, Hua ^{[1
]}

机构：

[1] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China

[2] Huaihua Univ, Coll Chem & Mat Engn, Huaihua 418008, Peoples R China

来源：

TETRAHEDRON | 2021年 / 83卷

基金：

中国国家自然科学基金;

关键词：

Intramolecular; 3+2]-cycloaddition; Tetracyclic skeleton;

D O I：

10.1016/j.tet.2021.131992

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient intramolecular [3 + 2]-cycloaddition of in situ-formed salicylaldehyde-based N,N'-cyclic azomethine imines was successfully developed to access novel tetracyclic skeleton bearing three contiguous stereogenic centres. This established protocol features high functional-group tolerance, excellent chemical yields, good diastereoselectivities, and variable reaction conditions. (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：5

共 24 条

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[24] SYNTHESIS OF NOVEL FUSED BETA-LACTAMS BY INTRAMOLECULAR 1,3-DIPOLAR CYCLO-ADDITIONS .7. (9RS,9ARS)-9,9A-DIHYDRO-5-METHYL-8-OXO-9-PHENOXYACETAMIDO-8H-AZETO[1,2-A]-V-TRIAZOLO[5,1-C]PYRAZINE-6-CARBOXYLIC ACIDS AND (3BRS,4RS,7SR)-4,5-DIHYDRO-5-OXO-4-PHENOXYACETAMIDO-3BH-AZETO[1',2'-3,4]-IMIDAZO[1,5-C]-V-TRIAZOLE-7-CARBOXYLIC ACID,
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